Taste signaling elements expressed in gut enteroendocrine cells regulate nutrient-responsive secretion of gut hormones
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چکیده
منابع مشابه
Taste signaling elements expressed in gut enteroendocrine cells regulate nutrient-responsive secretion of gut hormones.
Many of the receptors and downstream signaling elements involved in taste detection and transduction are also expressed in enteroendocrine cells where they underlie the chemosensory functions of the gut. In one well-known example of gastrointestinal chemosensation (the "incretin effect"), it is known that glucose that is given orally, but not systemically, induces secretion of glucagon-like pep...
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Glucagon-like peptide-1 (GLP-1), released from gut endocrine L cells in response to glucose, regulates appetite, insulin secretion, and gut motility. How glucose given orally, but not systemically, induces GLP-1 secretion is unknown. We show that human duodenal L cells express sweet taste receptors, the taste G protein gustducin, and several other taste transduction elements. Mouse intestinal L...
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ژورنال
عنوان ژورنال: The American Journal of Clinical Nutrition
سال: 2009
ISSN: 0002-9165,1938-3207
DOI: 10.3945/ajcn.2009.27462t